发明名称 |
Thienotriazolodiazepine compounds for treating neoplasia |
摘要 |
The invention features compositions for treating or preventing a neoplasia. More specifically, the invention provides thienotriazolodiazepine compounds for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail). |
申请公布号 |
EP2902030(A1) |
申请公布日期 |
2015.08.05 |
申请号 |
EP20140197043 |
申请日期 |
2011.05.16 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
BRADNER, JAMES ELLIOTT;QI, JUN |
分类号 |
A61K31/5517;A61K31/551;A61P35/00;C07D487/04;C07D495/12;C07D495/14;C07D519/00 |
主分类号 |
A61K31/5517 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|