The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.
申请公布号
EP2900257(A1)
申请公布日期
2015.08.05
申请号
EP20130770674
申请日期
2013.09.25
申请人
LEIDEN UNIVERSITY MEDICAL CENTER;2) UNIVERSITY OF MANITOBA
发明人
KIKKERT, MARJOLEIN;MARK, BRIAN LEONARD;KASTEREN VAN, PUCK BERTYNE;JAMES, TERRENCE WILLIAM;SNIJDER, ERIC JOHN
