| 主权项 |
1. A method treating rheumatoid arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, or ulcerative colitis, comprising treating a patient in need of such treatment with an effective amount of a compound having a structure of Formula (IIA), or a pharmaceutically acceptable salt thereof: wherein R6, R7, R8, and R9 are each independently alkyl, hydroxyl, alkoxy, NR13R14, halogen, nitro, cyano, borono, aryl, aryloxy, —(CH2)nCOOR15, —O(CH2)nCOOR16, —OC(O)R17, —CR18═NOH, —CR19R20NHOH, —SO3H, —SO2R21, —SO2NHR22, —O(CH2)mOR23, —C(OH)═NOH, —C(O)NR24OH, CHR25N(COR26)OH, or C(O)R27; or R8 and R9 together form —O—, —NHC(O)—, —C(O)NH—, —C(O)O—, —NR29—, or —S(O)2NH; R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R28, and R29 are each independently hydrogen, alkyl, or aryl, and R27 is alkyl or aryl; X is absent or is —O—, —NR28— or —S—; n and m are independently 0, 1, 2, 3, 4, 5, or 6; and t and u are independently 0, 1, 2, or 3. |
