N-sulfonylbenzamide compounds

摘要

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y1, Y2, Z, R1, R2 and R3 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.;

主权项

1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Z is a ‘C-linked’ 5- or 6-membered heteroaryl comprising (a) one or two nitrogen atoms or, when 5-membered, (b) one or two nitrogen atoms and one sulphur atom, said heteroaryl being optionally substituted on a ring carbon atom by F or Cl; Y1 is CN, F, CI or R4; Y2 is H or F; X is CH2 or S; R1 and R2 are each independently H, Cl, F, R5, Ar or Het1; R3 is H, F, R5, Ar or Het1; R4 is (C1-C4)alkyl optionally substituted by one to three F; R5 is (C1-C4)alkyl, optionally substituted by one to three F; or (C1-C4)alkyloxy, optionally substituted by one to three F; Ar is phenyl optionally substituted by one to three atoms or groups selected from the group consisting of Cl, F and R5; Het1 is a ‘C-linked’ 5- or 6-membered heteroaryl group comprising one or two nitrogen atoms, being optionally substituted by one to three substituents selected from A or B; A is attached to a Het1 ring carbon and is selected from the group consisting of Het2, NH2 and R4; B is attached to a Het1 ring nitrogen and is selected from the group consisting of ‘C-linked’ Het2 and R4; and Het2 is a ‘C-linked’ 3- to 8-membered saturated heterocyclic group comprising (a) one or two ring nitrogen atoms, or (b) one oxygen atom and one or two nitrogen atoms, said heterocyclic group being optionally substituted by R4.