| 主权项 |
1. A compound of Formula II:or a pharmaceutically acceptable salt thereof,
whereinA is bicyclic heteroaryl or bicyclic heterocycloalkyl selected from the group consisting of R1 is halo; R3 is heterocycloalkyl, or C1-6-alkyl-heterocycloalkyl wherein the heterocycloalkyl or C1-6-alkyl-heterocycloalkyl groups are optionally substituted with C1-4-alkyl; R4 and R5 are each independently selected from H, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, C1-6-alkyl-C3-6-cycloalkyl, heterocycloalkyl, C1-6-alkyl-heterocycloalkyl, NR6R7, O—C1-6-alkyl-OR8, C1-6-alkyl-OR8, aryl, C1-6-alkyl-aryl, heteroaryl, C1-6-alkyl-heteroaryl, C(O)N(R6)-heteroaryl, C(O)N(R6)-heterocycloalkyl, C(O)N(R6)-aryl, C(O)—NR6R7, C(O) -heteroaryl, C(O)-heterocycloalkyl, C(O)-aryl, C(O)—C1-6-alkyl, CO2-heteroaryl, CO2-heterocycloalkyl, CO2-aryl, CO2-C1-6-alkyl, or C(O)—C1-6-alkyl-heterocycloalkyl, wherein the cycloalkyl, heterocycloalkyl, aryl, or heteroaryl groups are optionally substituted with C1-4-alkyl, CO2R8, C(O)R8, or C1-6-alkyl-OR8; R6 and R7 are each independently selected from H, C1-6-alkyl, C1-6-alkyl-OR8, CO2R8, or C1-C6-alkyl-aryl; and R8 is H or C1-6-alkyl. |
