发明名称 |
GENE IMMUNIZATION USING AN ANTIGEN-CHAPERONIN FUSION |
摘要 |
<p>It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.</p> |
申请公布号 |
CA2583361(C) |
申请公布日期 |
2015.08.04 |
申请号 |
CA20052583361 |
申请日期 |
2005.10.14 |
申请人 |
SEKISUI CHEMICAL CO., LTD.;CHIBA, JOE |
发明人 |
CHIBA, JOE;HATA, JUN-ICHI;NISHIGUCHI, NAOKI;FURUTANI, MASAHIRO |
分类号 |
C12N15/09;A61K48/00;C12N5/12;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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