Graft-copolymer stabilized metal nanoparticles

摘要

There is provided a method of preparing nanoparticles and novel nanoparticles. The nanoparticle preparation comprises the generation of a mixture comprising a plurality of metal-containing compounds and a copolymer of a polyethylene glycol and an amine-containing polyamino acid such as polylysine where a metal core and polymer shell nanoparticle is formed. The novel nanoparticles have a metallic core and a graft copolymer shell of polyethylene glycol and an amine-containing polyamino acid where the shell least partially surrounds the metallic core and is non-ionically bound to the metallic core via metal-amine bonds.

主权项

1. A nanoparticle comprising:
a metallic core, and a copolymer shell of a polyethylene glycol and an amine-containing polyamino acid that at least partially surrounds the metallic core, wherein said copolymer shell is non-ionically bound to said metallic core via metal-amine bonds, and wherein said nanoparticle is a non-aggregating nanoparticle, and wherein said amine-containing polyamino acid is any of poly-L-lysine and poly-D-lysine.