Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer

摘要

Ophthalmic compositions that comprise 0.1 ppm to 50 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 2 wt. % of an anionic biopolymer; and 0.01 wt. % to 2 wt. % of an amphoteric surfactant of general formula I;wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C30alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from C1-C4alkyl; R4 is a C2-C8alkylene optionally substituted with hydroxyl; and Y is CO2− or SO3. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

主权项

1. An ophthalmic composition comprising:
0.01 wt. % to 2 wt. % of an amphoteric surfactant of general formula I wherein Rl is a C8-C16 alkyl; R2 and R3 are methyl; R4 is a C2-C4 alkylene; and Y is SO3 −; 0.5 ppm to 2 ppm of α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride; 0.5 ppm to 2.0 ppm poly(hexamethylene biguanide); 0.01 wt. % to 0.05 wt. % ethylenediaminetetraacetic acid or a corresponding salt thereof; a borate buffer; and 0.002 wt. % to 0.03 wt. % of hyaluronic acid, wherein the ophthalmic composition satisfies the biocidal requirements of Stand-Alone Procedure for Disinfecting Products.