KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

摘要

Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions com .pi.sin them and methods of their use, X is O or NR A; Y is O, NR R, or C(R R)2; A is cycloalkyl, aryl or heterocycle; R A is hydrogen, cyano, nitro, R A1, SO2R A1, SO2NR A1, or SO2N(R A1)2;