Polyesteramide platform for site specific drug delivery

摘要

A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

主权项

1. A composition comprising:
a polymer selected from the group consisting of (i) a first poly(ester amide) polymer comprising the reaction product of a diacid, a diol and a first amino acid and (ii) a second poly(ester amide) polymer comprising the reaction product of an amidediol and a diacid as base components; a therapeutic agent; and an at least partially water miscible solvent.