主权项 |
1. A nanoparticle comprising:
a first polyvalent carrier domain wherein the first polyvalent carrier domain is made up of more positively ionizable moieties than negatively ionizable moieties, a second polyvalent carrier domain wherein the second polyvalent carrier domain is made up of more negatively ionizable moieties than positively ionizable moieties, wherein the first and second polyvalent carrier domain comprises a polyamide, polysaccharide, polyacetal, polyester, polyamine, polyallylamine, polyimine, polyethyleneimine, or aminodextran; and an ionizable biologically active agent covalently coupled to the first or second polyvalent carrier domain; wherein said biologically active agent comprises an antigen, a chemotherapeutic agent, or a nucleic acid; wherein said nanoparticle has an average size from about 0.1 to about 1.0 micron; and wherein the first polyvalent carrier domain comprises biocompatible material; provided by metabolic degradation or excretion and wherein said first polyvalent carrier domain has a molecular weight of less than about 20,000 Daltons. |