Method for determining lymph node metastasis in cancer or risk thereof and rapid determination kit for the same

摘要

The objective of the present invention is to provide a method and a means of rapidly and reliably detecting lymph node metastasis in cancer or the risk of lymph node metastasis. Specifically, the present invention provides a method and a rapid determination kit for detecting lymph node metastasis in cancer or its risk by identifying a certain genetic polymorphism of the human CRP gene, and it is clinically significant in determining the treatment strategy, because effective prediction/determination can be made regarding lymph node metastasis, which is an important phenomenon in cancer progression.

主权项

1. A method of treating cancer in a human subject, comprising:
obtaining a biological sample from the subject, said sample comprising nucleic acids from the subject; detecting a T/T genotype of SNP rs1205 in human C-reactive protein (CRP) gene in the nucleic acids; correlating the presence of said T/T genotype of SNP rs1205 with an increased risk of lymph node metastasis in the subject; and administering to the subject a cancer treatment involving lymph node dissection.