| 主权项 |
1. A compound of formula Ior a pharmaceutically acceptable salt thereof; wherein L is chosen from: wherein L is substituted with 0, 1, 2, or 3 independently chosen R5; W is chosen from C1-10 alkylamino, a 3-15 member saturated, unsaturated or partially saturated monocyclic or bicyclic ring system containing 0, 1, 2, 3, or 4 atoms independently selected from N, O, or S, and —NR6R6 wherein two R6 and the nitrogen to which they are attached can optionally form a -4, -5, or -6 member saturated ring system, and wherein W is substituted with 0, 1, 2 or 3 independently chosen R5; Calkoxy, C alkylsulfonyl, (C alkyl)sulfonylamino, R6 is independently selected from: hydrogen, (carbonyl)0-1C1-10 alkyl, (carbonyl)0-1C2-10 alkenyl, (carbonyl)0-1C2-10 alkynyl, C0-10 alkylcarbonyl(oxy)0-1C0-10 alkyl, C1-10 alkyl(oxy)0-1carbonylC0-10 alkyl, C2-10 alkenylcarbonyl, C2-10 alkynylcarbonyl, (C1-10)alkyl(oxy)0-1C0-10 alkyl, aryl(oxy)0-1C0-10 alkyl, (C3-8)heteroaryl(oxy)0-1C0-10 alkyl, C3-8 cycloalkyl(oxy)0-1C0-10 alkyl, (C3-8)heterocycloalkyl(oxy)0-1C0-10 alkyl, (C1-10)heteroalkyl(oxy)0-1C0-10 alkyl, C0-10 alkyl(oxy)0-1C0-10 alkylaminocarbonylC0-10 alkyl, C0-10 alkylaminocarbonylC1-10 heteroalkyl, C0-10 alkylaminocarbonyl(C3-8)heterocycloalkylC0-10 alkyl, C0-10 alkylaminocarbonyl(C3-8)heteroarylC0-10 alkyl, C0-10 alkylaminocarbonyl(C3-8)cycloalkylC0-10 alkyl, C0-10 alkylaminocarbonylarylC0-10 alkyl, hydroxy C0-10alkyl, C0-10 alkylsulfonyl, aryl C1-10 alkylsulfonyl, C3-8 heterocyclyl C1-10 alkylsulfonyl, C3-8 heterocycloalkyl C1-10 alkylsulfonyl, C3-8 cycloalkyl C1-10 alkylsulfonyl, and C1-6 haloalkyl; R1, R2 and R5 are independently chosen from (1-methylethyl)carbamoyl, (2-methoxyethyl)carbamoyl, (2-hydroxy-ethyl)carbamoyl, (tetrahydro-2H-pyran-4-yl)carbamoyl, azetidin-1-ylcarbonyl, 2-methylpropylcarbamoyl, carbamoyl, (tetrahydrothiophen-3-yl)carbamoyl, (1H-pyrazol-5-ylmethyl)carbamoyl, (4-hydroxypiperidin-1-yl)carbonyl, cyclopropylmethylcarbamoyl, sulfamoyl, dimethylsulfamoyl, amino, acetylamino, sulfonylamino, propanoylamino, (propan-2-ylcarbamoyl)amino, (propylcarbamoyl)amino, carbamoylamino, methylcarbamate, ethylcarbamate, (1-methylethyl)carbamate, 1H-pyrazolyl, tertbutoxymethyl, (methoxyethyl)piperazinyl, 2-morpholin-4-ylethoxy)methyl, (prop-2-en-1-yloxy)methyl, piperidinylmethoxy, pyrrolidin-1-ylmethyl, methoxymethyl, cyclopentanylcarboxamidomethyl, propanoylamino)methyl, (cyclohexanecarbonylamino)methyl, but-2-enoylaminomethyl, (cyclopropylcarbonyl)aminomethyl, (1,3-oxazol-5-yl)carbonylaminomethyl, (butanoylamino)methyl, (pyrrolidin-1-ylcarbonyl)aminomethyl, halogen, cyano, carbamoyl, methoxy, trifluoroethyl, methylsulfonyl, hydroxyl, 2-methoxyethoxy, methylethoxy, benzyloxy, cyclopentyloxy, cyclopropylmethoxy, 2-phenylethoxy, 2,3-dihydro-1H-inden-2-yloxy, tetrahydro-2H-pyran-4-yloxy, 2-oxopyrrolidin-1-yl)ethoxy, pyridin-3-ylmethoxy, 2-pyridin-2-ylethoxy, 2-(dimethylamino)ethoxy, 3-(dimethylamino)propoxy, 2-morpholin-4-ylethoxy, 1-methylpiperidin-4-yl)oxy, 2-(piperazin-1-yl)ethoxy, hydrogen, and piperidin-4-yl)methoxy, wherein R1, R2 and R5 are independently substituted with 0, 1, 2, or 3 substituents R3; wherein R1, R2, R5 and R6 are independently substituted with 0, 1, 2, or 3, substituents R3 chosen from: halogen, C1-C10 alkyl, CF3, NH2, N(C1-C6 alkyl)2, NO2, —(C0-6)alkylCN, —OH, —O(C1-C6 alkyl), C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C0-C6 alkyl) S(O)0-2—, (C0-C6 alkyl)S(O)0-2(C0-C6 alkyl)-, (C0-C6 alkyl)C(O)NH—, H2N—C(NH)—, —O(C1-C6 alkyl)CF3, (C0-C6 alkyl)C(O)—, (C0-C6 alkyl)OC(O)—, (C0-C6 alkyl)O(C1-C6 alkyl)-, (C0-C6 alkyl)C(O)1-2(C0-C6 alkyl)-, (C0-C6 alkyl)OC(O)NH—, —NH(C1-C6 alkyl)NHC(O)NH(C1-C6 alkyl), NHC(O)OC1-C6 alkyl, —NH(C1-C6 alkyl)NHSO2(C1-C6 alkyl), —(C0-C6 alkyl)NHSO2(C1-C6 alkyl), C1-10alkoxy, —CO2(C0-10 alkyl), Oxo (═O), trifluoromethyl, trifluoroethyl, C1-10 alkylsulfonyl, —SO2N(C1-6alkyl)1-2, —SO2CF3, —SO2CF2H, —C1-10 alkylsulfinyl, —O(0-1)(C1-10)haloalkyl, aryl, heteroaryl, heterocyclyl, halo-aryl, halo-heterocyclyl, cyano-aryl, cyano-heteroaryl, and cyano-heterocyclyl. |
