| 摘要 |
Provided is a composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant. |
| 主权项 |
1. A composition preventing tissue adhesion comprising:
a first aqueous solution of:
a) 1 to 50 wt % of a block copolymer having 1,000 to 500,000 g/mol of molecular weight and comprising a polyethyleneoxide block; andb) 0.1 to 4 wt % of a polymer of 10,000 to 1,000,000 g/mol of molecular weight capable of being mixed with the a) block copolymer; and a second aqueous solution of:
c) 0.01 to 2 wt % of a cross-linking agent; wherein said composition comprises a combination of the first aqueous solution and second aqueous solution,wherein the cross-linking agent is one or more selected from the group consisting of acetate or halide compounds including one or more cations selected from the group consisting of Mg2+, Mn2+, Ca2+, Cu2+, Sr2+, Ba2+, Fe2+, and Co2+; chitosan; chitosan; glutaraldehyde; formalin; poly-L-lysine; dopamine; isoleucine, phenylalanine, leucine, threonine, lysine, tryptophan, methionine, valine, histidine, alanine, arginine, asparagine, aspartate, cysteine, glutamine, glutamate, glycine, proline, serine and tyrosine; andwherein the second aqueous solution is added into the first aqueous solution at a spraying rate of 10 to 100 ml/min, in which a difference of viscosity between the upper and lower liquid layers is within 10% when centrifuging the composition for 3 minutes at 3,000 rpm and 25° C. |
