Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such

摘要

Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.

主权项

1. A method for enhancing memory comprising administering to a patient that is predisposed to developing a neurodegenerative disease a memory enhancing amount of the following compound: