Peptide compounds and methods of production and use thereof

摘要

Peptide compounds based on the CAP37 (cationic antimicrobial protein of Mr 37 kDa) protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.

主权项

1. A composition comprising a peptide compound of Formula (I):
SM-XR-Pep-YR wherein: Pep is one of SEQ ID NOs: 1-7; XR and YR are each independently 0, 1, 2, 3, 4, or 5 arginine residues, with the proviso that (XR+YR) is 4, or 5 arginine residues; and SM is a solubilizing moiety of one of (1)-(3), wherein: (1) is [2-(2-amino-ethoxy)-ethoxy]-acetic acidk (AEEAk), where k=1-5; (2) is {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acidk (AEEEAk), where k=1-5; or (3) is a combination of AEEAm and AEEEAn subunits, wherein m=1-9 and n=1-9 with the proviso that (m+n) is 2, 3, 4, 5, 6, 7, 8, 9, or 10, and wherein the AEEAm and AEEEAn subunits are arranged in any order.