Methods and compositions for modulation of Olfml3 mediated angiogenisis

摘要

The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.

主权项

1. A pharmaceutical composition comprising a monoclonal antibody, or a nucleic acid encoding the antibody, and a pharmaceutically acceptable carrier, wherein the antibody recognizes and binds to (i) epitope within amino acid positions 86-99 of SEQ 1D NO:1 (human Olfml3 protein), or (ii) an epitope within amino acid positions 390-403 of SEQ ID NO: 1, inhibits the binding of human Olfml3 protein to BMP4 protein, and reduces the number of pericytes in vessels.