Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism

摘要

The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

主权项

1. A compound of formula (XXII): wherein: n=1 to 5; R1 to R4 are H; and R5 and R6 are independently selected from the group consisting of H, methyl, ethyl, n-prolyl, iso-prolyl, n-butyl, iso-butyl, tert-butyl, phenyl, tolyl, benzyl.