Cancer vaccines and vaccination methods

摘要

Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.

主权项

1. A composition comprising isolated dendritic cells that present on human leukocyte antigen (HLA) on their surface peptide epitopes of the following six antigens: tyrosinase-related protein (TRP)-2, Melanoma-associated Antigen-1 (MAGE-1), HER-2, interleukin-13 receptor α2 (IL-13 receptor α2), gp100, and Antigen isolated from Immunoselected Melanoma-2 (AIM-2), wherein the dendritic cells acquired the peptide epitopes in vitro by exposure to six synthetic peptides from the six antigens each of which are 9 to 13 amino acids in length and wherein five of the six synthetic peptides comprise the following amino acid sequences:(SEQ ID NO: 3)RSDSGQQARYfrom AIM-2;(SEQ ID NO: 4)EADPTGHSYfrom MAGE-1;(SEQ ID NO: 5)SVYDFFVWLfrom TRP-2;(SEQ ID NO: 37)VMAGVGSPYVfrom HER-2;and(SEQ ID NO: 8)WLPFGFILIfrom IL-13 receptor α2.