发明名称 Substituted aryloxazoles and their use
摘要 The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
申请公布号 US9095582(B2) 申请公布日期 2015.08.04
申请号 US201313893344 申请日期 2013.05.14
申请人 Bayer Intellectual Property GmbH 发明人 Nell Peter;Hübsch Walter;Albrecht-Küpper Barbara;Keldenich Jorg;Vakalopoulos Alexandros;Süssmeier Frank;Zimmermann Katja;Lang Dieter;Meibom Daniel
分类号 C07D413/14;A61K31/443;A61K31/4439;C07D413/12;C07D419/14;A61K31/695;A61K45/06;C07F7/10 主分类号 C07D413/14
代理机构 代理人 King Karen B.
主权项 1. A compound of the formula (I)in which A represents O or S, R1 represents hydrogen or (C1-C4)-alkyl, R2 represents hydrogen or (C1-C4)-alkyl which may be substituted by hydroxyl, (C1-C4)-alkoxy or up to three times by fluorine or R1 and R2 are attached to one another and together with the carbon atom to which they are attached form a cyclopropane or cyclobutane ring, R3 represents hydrogen, halogen or (C1-C4)-alkyl, R4 and R5 together with the nitrogen atom to which they are attached form a pyrrolidino ring which may be mono- or disubstituted by identical or different substituents from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy, and either (i) R6 represents (C6-C10)-aryl which may be mono- to trisubstituted by identical or different substituents from the group consisting of halogen, nitro, cyano, (C1-C4)-alkyl, trifluoromethyl, hydroxyl, (C1-C4)-alkoxy, difluoromethoxy, trifluoromethoxy, mono-(C1-C4)-alkylaminocarbonyl, (C1-C4)-alkoxycarbonyl and carboxyl, and R7 represents hydrogen, fluorine, chlorine, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxycarbonyl, carboxyl or phenyl, where (C1-C4)-alkyl may be substituted by hydroxyl or (C1-C4)-alkoxy and phenyl may be substituted by halogen, cyano, (C1-C4)-alkyl or trifluoromethyl, or (ii) R6 represents hydrogen or (C1-C4)-alkyl and R7 represents phenyl which may be mono- or disubstituted by identical or different substituents from the group consisting of halogen, cyano, (C1-C4)-alkyl and trifluoromethyl, or a salt thereof.
地址 Monheim DE