| 发明名称 | Compounds for treatment of cell proliferative diseases | ||
| 摘要 | The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines. | ||
| 申请公布号 | US9096499(B2) | 申请公布日期 | 2015.08.04 |
| 申请号 | US201414147089 | 申请日期 | 2014.01.03 |
| 申请人 | Board of Regents, The University of Texas System | 发明人 | Priebe Waldemar;Donato Nicholas;Talpaz Moshe;Szymanski Slawomir;Fokt Izabela;Levitzki Alexander |
| 分类号 | C07C255/44;C07C255/41;C07C255/42;C07D213/57;C07D213/61;A61K31/277;A61K45/06 | 主分类号 | C07C255/44 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. A compound of the formula: wherein: R2 is alkyl, alkoxy, halogen, hydrogen, OH, NO2, amine or NH2 Y1 is halogen or NO2; X1, X2, X3, and X4 are each independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, OH, trihalomethyl and NO2, provided that at least one of X1, X2, X3, and X4 is selected from alkyl, alkoxy, OH and trihalomethyl; and X5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Austin TX US | ||