Osseointegration and biointegration coatings for bone screw implants

摘要

Novel orthopaedic bone screws/spinal pedicle screws and implants that include coatings to help promote a structurally stable interface between the implant and the patient's bone/tissue, and methods of coating such screws and implants are provided. The implants and methodologies described involve at least a coating that facilitates osseous integration, and additionally at least one coating that either reduces the risk of infection in immunologically suppressed patients and/or for utilization in patients who have infection, but who require stabilization, or coatings that permit the use of dissimilar metals and prevent galvanic corrosive reactions.

主权项

1. An implant screw for permanent use in a patient comprising:
an elongated shafted having a threaded portion for engaging a bone of the patient disposed along a distal portion thereof, an exposed head portion disposed at a proximal end thereof, and a fixture engaging portion disposed between said threaded portion and said exposed head portion; a porous and non-dissolvable biomimetic coating disposed on at least the portion of the thread configured to engage a bone, the biomimetic coating forming a non-dissolving interfacial binding region between the implant screw and the bone, said interfacial binding region comprising at least the biomimetic coating and bone; a dielectric coating disposed on at least the exposed head portion and the fixture engaging portion of the implant screw, the dielectric coating insulating the implant from secondary corrosive currents; and an infection preventative material, selected from one or all of an antimicrobial, an antibacterial or an antiseptic material, such infection preventative material being incorporated into at least the biomimetic coating, said infection preventative material continuously releasing a dose of an infection preventative material above a minimum inhibitory concentration into a region immediately adjacent said implant.