发明名称 Pyrazolopyrimidine derivatives as PI3 kinase inhibitors
摘要 PI3Kβ selective compounds having the structure;
申请公布号 US9096605(B2) 申请公布日期 2015.08.04
申请号 US201214233896 申请日期 2012.06.29
申请人 GlaxoSmithKline LLC 发明人 Lin Hong;Luengo Juan Ignacio;Moore Michael Lee;Qu Junya;Rivero Ralph A.;Tedesco Rosanna;Yu Hongyi
分类号 C07D413/04;C07D487/04 主分类号 C07D413/04
代理机构 代理人 Young J. Scott
主权项 1. A compound of formula (I): wherein R1 is H, C1-6alkyl, —OH, C1-6alkoxy, NH2, or CF3; each R2 is selected independently from C1-6alkyl, halo, CF3, and the R2s are located ortho and meta on the phenyl group; R3 is H, —CN, OH, NH2, halo, C1-6alkyl, C1-6alkoxy, —C(O)Ra, —NH(O)Ra, ═O, or a 5 or 6 membered heterocycle containing 1-3 heteroatoms selected from N and O; R4 is a 5 or 6 membered heterocycle or 5 or 6 membered heteroaryl containing 1-3 heteroatoms selected from N and O, optionally substituted with C1-6alkyl or ═O; Ra is OH, NH2, or C1-6alkyl; and n is 2, or a pharmaceutically acceptable salt thereof.
地址 Wilmington DE US