| 摘要 |
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:;
wherein A, L, R1, R2, R4, and R5 are defined herein. |
| 主权项 |
1. A compound of Formula (I)wherein
A is thienyl or C5-7cycloalkyl; R1 is one to three substituents selected from the group consisting of hydrogen, C1-4alkyl, C1-4alkoxy, fluoro, chloro, and hydroxy; L is —Z—(CH2)n— or —CH2—; n is 0 or 1; Z is NR3; R2 is hydrogen, C1-4alkyl, C1-4alkoxy, trifluoromethyl, chloro, fluoro, bromo, carboxy, or C1-4alkoxycarbonyl; R3 is hydrogen or C1-3alkyl; R4 is hydrogen or C1-4alkyl; R5 is isoquinolinyl; wherein R5 is optionally substituted with 1 to 2 substituents independently selected from the group consisting of C1-4alkyl, hydroxy, C1-4alkoxy, trifluoromethyl, chloro, fluoro, bromo, carboxy, C1-4alkoxycarbonyl, and cyano; and enantiomers, diastereomers, or a pharmaceutically acceptable salts thereof. |
