Arrangement and method for producing high-purity crystals

摘要

An arrangement and a method for producing high-purity crystals, such as temperature-sensitive pharmaceutical agents, in a countercurrent crystallization process. The arrangement comprises a plurality of crystallizers, mother liquor lines, each of which has a shut-off valve, and crystallization product lines, each of which has a shut-off valve, so that a mother liquor flow can be generated which is directed from a crystallizer to the second-next crystallizer in the direction of decreasing purity, and a crystallization product flow can be generated which is directed from a to dissolved crystallization product that is about to crystallize to the next crystallizer in the direction of higher purity.

主权项

1. An apparatus for producing high-purity crystals, comprising:
a plurality of crystallizers; a plurality of crystallization product lines, each having a shut-off valve; a plurality of mother liquor lines, each having a shut-off valve; a storage vessel for waste; a storage vessel for pure product; a storage vessel for fresh solvent or distillate, the storage vessel for fresh solvent or distillate in connection with a plurality of supply lines, each of the supply lines having a shut off valve, each of the supply lines feeding one of the crystallizers; a plurality of condensers; the mother liquor lines connecting one of the crystallizers from among the plurality of crystallizers with one of a next-adjacent crystallizer from among the plurality of crystallizers and the storage vessel for waste; the number of mother liquor lines in the plurality of mother liquor lines being sufficient to connect one of the crystallizers from among the plurality of crystallizers with one of a next-adjacent crystallizer from among the plurality of crystallizers and the storage vessel for waste; the crystallization product lines connecting one of the crystallizers from among the plurality of crystallizers with one of an adjacent crystallizer from among the plurality of crystallizers and the storage vessel for pure product; the number of crystallization product lines in the plurality of crystallization product lines being sufficient to connect one of the crystallizers from among the plurality of crystallizers with one of an adjacent crystallizer from among the plurality of crystallizers and the storage vessel for pure product; whereby flow through a path formed by the mother liquor lines is countercurrent to flow through a path formed by the crystallization product lines, with flow through the plurality of mother liquor lines decreasing in purity and flow through the crystallization product lines increasing in purity.