SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF

摘要

A method is provided for indicating whether a human has an increased risk for a myocardial infarction (MI), or whether a human's risk for MI is reduced by treatment with an HMG-CoA reductase inhibitor, e.g. a statin such as pravastatin, atorvastatin, simvastatin, cerevastatin, or lovastatin. The method comprises testing nucleic acid from the human for presence or absence of a single nucleotide polymorphism at position 101 of SEQ ID NO:205 or its complement. Presence of T at position 101 of SEQ ID NO:205 or A at position 101 of the complement indicates that the human has increased risk for MI and that the risk is reduced by such treatment. Also provided are polynucleotides useful for such testing.