Method of filtering platelets to remove antiplatelet and anticoagulant agents

摘要

The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.

主权项

1. A method for removing antiplatelet agents and anticoagulants from a platelet preparation, comprising:
flowing a platelet preparation comprising an antiplatelet agent, an anticoagulant and platelets through a filtering tube comprising a filtering membrane and separating the antiplatelet agent and anticoagulant from the platelet preparation by tangential flow filtration, wherein the antiplatelet agent comprises a GPIIb/IIIa inhibitor and has a circulating half-life of inhibition of 4 hours or less and wherein the filter membrane has a pore size ranging from molecular cut off of 3000 daltons to 0.5 micron and wherein the anticoagulant comprises a short-to-ultrashort acting factor Xa inhibitor.