Methods of evaluating BAFF

摘要

The present disclosure provides compositions and methods relating to the evaluation of BAFF in a biological sample from a subject.

主权项

1. A method of evaluating the distribution of BAFF, the method comprising;
(a) contacting a first biological sample with a first anti-BAFF antibody, which binds BAFF independent of whether BAFF is bound to a receptor; (b) contacting a second biological sample, of the same type as the first, with a second anti-BAFF antibody, which preferentially binds free BAFF over BAFF bound to receptor; and (c) comparing the binding of the first antibody and the binding of the second antibody in the two samples,wherein the comparison in (c) indicates the distribution of BAFF among various physiological pools in the samples.