Surface-coated structures and methods

摘要

The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.

主权项

1. A method of preventing or inhibiting biofilm formation by a non-Pseudomonas bacteria on the surface of an article comprising the step of:
applying to the surface of the article, a D-form or retro-inverso synthetic pilin peptide containing a disulfide loop having the sequence identified as SEQ ID NO:10 and 0-10 additional residues on either or both the N- or C-terminal side of the loop, in an amount effective to inhibit biofilm formation by such non-Pseudomonas bacterium.