Methods of killing myeloma stem and precursor cells by administering anti-CD48 antibodies

摘要

The present invention provides a therapeutic agent, for diseases in which neoplastic proliferation of plasma cells occurs, which is characterized by containing an anti-human CD48 monoclonal antibody and having cellular cytotoxicity to cells expressing human CD48; and the monoclonal antibody. In addition, the present invention provides a method for screening an active ingredient of a therapeutic agent for diseases in which neoplastic proliferation of plasma cells occurs, the method including the following processes:
(1) a process of sorting a substance that binds specifically to human CD48; and(2) a process of sorting a substance having cellular cytotoxicity.

主权项

1. A method of treating multiple myeloma in a patient, comprising administrating to a patient having multiple myeloma an anti-human CD48 monoclonal antibody, wherein said treatment kills myeloma stem cells and/or myeloma precursor cells.