High frequency application of botulinum toxin therapy

摘要

The present invention relates to methods for treating diseases and disorders by administering a composition containing the neurotoxic component of a Clostridium botulinum toxin complex, wherein the composition is devoid of any other protein of the Clostridium botulinum toxin complex and wherein the composition is administered at short intervals and/or in high doses.

主权项

1. A method of treating a disease or condition caused by or associated with hyperactive cholinergic innervation of muscles or exocrine glands in a patient, the method comprising administering a composition comprising a therapeutically effective amount of a neurotoxic component of a Clostridium botulinum toxin complex serotype A, the composition being devoid of any other protein component of the Clostridium botulinum toxin complex, to remove partially or completely the treated disease or condition symptoms, wherein
(a) the patient is a human; (b) the composition is locally administered by injection of a non-lethal dose to a muscle or exocrine gland exhibiting hyperactive cholinergic innervation; (c) the composition is administered at an interval of less than eight weeks, the interval comprising a first treatment and a second treatment, wherein the amount administered in the second treatment can be lower, higher or identical to the amount administered in the first treatment.