发明名称 |
IDNA-vacciner og fremgangsmåder til deres anvendelse |
摘要 |
<p>Described herein are iDNA vectors and vaccines and methods for using the same. The iDNA generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly yellow fever virus and Venezuelan equine encephalitis virus. When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.</p> |
申请公布号 |
DK2310510(T3) |
申请公布日期 |
2015.08.03 |
申请号 |
DK20090798313T |
申请日期 |
2009.07.17 |
申请人 |
MEDIGEN, INC. |
发明人 |
PUSHKO, PETER;LUKASHEVICH, IGOR |
分类号 |
C12N15/65;A61K39/12;A61K48/00;C12N5/00;C12N15/85 |
主分类号 |
C12N15/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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