发明名称 |
QUINOXALINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS |
摘要 |
<p>The present invention relates to compounds of Formula (I) or (II), or a pharmaceutically acceptable salt, ester, or prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.</p> |
申请公布号 |
HK1140214(A1) |
申请公布日期 |
2015.07.31 |
申请号 |
HK20100106789 |
申请日期 |
2010.07.13 |
申请人 |
ENANTA PHARMACEUTICALS INC. |
发明人 |
NAKAJIMA, SUANNE;SUN, YING;TANG, DATONG;XU, GOUYOU;PORTER, BRIAN;OR, YAT, SUN;WANG, ZHE;MIAO, ZHENWEI |
分类号 |
C07K;A61K;A61K31/00;A61K31/38;A61K31/395;A61P;A61P31/12;C07D;C07D401/12;C07D409/14;C07D487/04;C07K5/083 |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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