| 摘要 |
<p>The collection device inserted into a hollow nozzle of needle or catheter type and lead out of a connector contacted in vivo with a particular body fluid containing a biological target to be removed, comprises: a frame (5) microstructured by openings (5b); and a biocompatible, porous and cross-linked polymer layer that comprises a support catch for capturing the target and is adapted to retain a screw-in support against the fluid and to pass only the particles of the fluid at a smaller size limit. The polymeric layer fills some or all of the openings retained by the frame. The collection device inserted into a hollow nozzle of needle or catheter type and lead out of a connector contacted with an in vivo taken body fluid containing a biological target to be removed, comprises: a frame (5) microstructured by openings (5b); and a biocompatible, porous and cross-linked polymer layer that comprises a support catch for capturing the target and is adapted to retain a screw-in support against the fluid and to pass only the particles of the fluid including the target at a smaller size limit. The polymeric layer fills some or all of the openings retained by the frame. The frame is deformable between positions where it is inserted in a tip and where it opens out of the tip. The frame is registered in a cylindrical surface of larger cross-dimension of 500 microns to 2 mm. The armature has an external face (5a) and defines an internal volume. The polymer layer extends through the openings of the internal volume to the outer face and beyond the internal volume. The frame has a single longitudinal axis of symmetry which is parallel to that of the nozzle, and retains a tubular geometry in the positions. The polymer layer has a viscosity, measured by a plane-cone rheometer, of 150-5800 mPa.seconds. The frame is a mesh, woven or braided type. The openings are separated one from another at a pitch of 30-60 mu m. The frame has a thickness of 10-100 mu m. The cylindrical surface has a circular or elliptical section. The external face and/or an inner face of the frame has depressions and/or reliefs that are distinct from the openings and have dimensions of 20-90 mu m. The polymeric layer forms, with respect to the external face of the frame, an outer coating coaxial with the frame and having a thickness of 50-300 mu m. The polymer layer has a Young's modulus, measured from compression tests made with a rheometer, of 50-270 kPa. The frame is embedded in the polymer layer on a part of its axial length of 1 mm to 5 cm. The polymer layer has a volume of 1-10 ml. Independent claims are included for: (1) a sampling system; and (2) a method for manufacturing a sampling device.</p> |
