| 摘要 |
<p>Use of phospho-Akt as a biomarker for predicting the response, such as resistance, to compounds, wherein phospho-Akt is Akt that has been phosphorylated on one or more residues, with the proviso that for Akt1, Akt2, and Akt3 the designation phospho-Akt is used to indicate phosphorylation at a site other than T308, T309 or T305 respectively, wherein the compounds are microtubule destabilizing agents of general formula (I), wherein the substituents are as described in the specification. Methods of treatment of neoplastic and autoimmune diseases with these compounds are also disclosed.</p> |
