VEGF AND PDGFRΒ BISPECIFIC FUSION PROTEIN AND USE THEREOF

摘要

Provided are a VEGF and PDGFRβ bispecific fusion protein and a use thereof. More particularly, provided is a dual functional fusion protein comprising a VEGFR extracellular ligand binding domain and a PDGFRβ antibody fragment, which can be used for treating wet age-related macular degeneration (AMD) and any other diseases which can be ameliorated by inhibiting the VEGF and PDGF signaling pathways, such as tumours and diabetic retinopathy.