USE OF A PANEL OF URINARY CYTOKINES TO PREDICT RESPONSE TO BCG THERAPY FOR BLADDER CANCER

摘要

Methods for predicting cancer recurrence following a BCG immunotherapy are provided. In some aspects, cytokine levels from a patient are measured before and after a BCG therapy and the changes in cytokine levels are used to determine the risk of cancer lapse. Methods for selecting a patient for a further anti-cancer therapy are also provided.

主权项

1. An in vitro method to predict a prognosis in a cancer patient following a BCG therapy, comprising:
obtaining at least two samples from the patient, the samples obtained both before and after BCG therapy; measuring changes in the levels of at least 3 cytokines in the samples, said at least 3 cytokines selected from the group consisting of IL-2, IL-6, IL-8, IL-18, IL-1ra, IL-1B, TRAIL, IL-10, IFN-γ, IL-12(p70), IL-12(p40) and TNF-α; and identifying whether the patient is at risk for relapse based on the measured changes in cytokine levels.