Methods and Compositions For Stimulating Neurogenesis and Inhibiting Neuronal Degeneration

摘要

The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, and depression. This invention could also be used for research products including single agents or mixtures of agents to promote, proliferate, differentiate, or maintain neurons from stem or progenitor cells.

主权项

1. A method for stimulating neurogenesis and/or inhibiting neuronal degeneration in a mammal comprising, administering, to a mammal in need thereof a pharmaceutical composition comprising a compound of the formula: wherein
each R1 is independently selected from the group consisting of H, F, Cl, Br, R7, and —O—R7, wherein R7 is a substituted 1-6 carbon alkyl or a 6-14 carbon aryl or aralkyl group;R2 is selected from O or S;R3 is (CH2)m, wherein m is 1, 2 or 3;R4 is selected from the group consisting of an N and (CHn), wherein n equals 1 or 2, with the proviso that when R4 is nitrogen then m in R3 should not be equal to 1;R5 is a substituted heterocyclic aromatic group, except where R5 is 4-quinolinyl the substitution at the 2′ position cannot be H or an amino group;R6 is H; anda pharmaceutically acceptable carrier in an amount effective to stimulate neurogenesis and/or inhibit neuronal degeneration in the mammal.