| 摘要 |
Disclosed are an o-phenyl chalcone compound and preparation method and use thereof The o-phenyl chalcone compound is capable of inhibiting the aggregation assembly of microtubules in tumour cells and influencing the mitosis of the cells, and has a high antitumour activity, and has the effect that the median inhibitory concentration of the proliferation inhibition on various tumour cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like, is mostly up to the level of nmol/l. In addition, the o-phenyl chalcone compound is capable of effectively resisting various multidrug resisting tumours resistant to clinical drugs, such as taxol, vinblastine, adriamycin and cisplatin; compared with the existing clinical representative drugs, such as adriamycin, taxol, colchicines and vincristine, the o-phenyl chalcone compound disclosed in the present invention not only has a remarkable advantage in the aspect of resisting drug-resistant tumours, but also has the important advantages of a novel structure, simple synthesis, cheap raw materials, good solubility and the like in the aspect of physicochemical properties. |
