| 主权项 |
1. A compound of Formula I, wherein: R1 is hydrogen or Rd; R2 and R3 are each independently selected from hydrogen and Rd; Rd is independently selected from —O(R18), —C(O)R19, and —C(O)R20—O—C(O)—R21, wherein R18 is independently selected from hydrogen, (C1-C6)alkyl, (C6-C10)aryl, and (C6-C10)alkylaryl; wherein R19 is independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkoxyalkyl, (C6-C10)alkoxyaryl, (C6-C10)aryl, and (C6-C10)alkylaryl; wherein R20 is independently selected from (C1-C6)alkyl; and wherein R21 is independently selected from (C1-C6)alkyl, (C6-C10)aryl, and (C6-C10)alkylaryl; V is —C(R4R5)—, —N(R6)—, —O—, —C(O)—, or —S—; wherein R4 and R5 are each independently selected from hydrogen, NH2, OH, and (C1-C4)alkyl, or R4 and R5, together with the atom to which they are attached form a saturated or unsaturated 3- to 8-membered ring, wherein said 3- to 8-membered ring is optionally substituted with at least one heteroatom, wherein the at least one heteroatom is independently selected from O, S, N, and NR7, wherein R7 is hydrogen or (C1-C3)alkyl, and wherein said 3- to 8-membered ring is optionally substituted by at least one substituent independently selected from OH, N(ReRf), halo, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, and (C1-C10)alkoxyalkyl; and R6 is hydrogen or (C1-C4)alkyl; W is present or absent, but when present, is —C(R8R9)—, —N(R10)—, or —C(O)—; wherein R8 and R9 are each independently present or absent, but when present, they are each independently selected from hydrogen, (C1-C4)alkyl, OH, and ═NH, or R8 or R9 together with the atom to which they are attached optionally form a saturated or unsaturated 3- to 8-membered ring, wherein said 3- to 8-membered ring is optionally substituted with at least one heteroatom, wherein the at least one heteroatom is independently selected from O, S, N, and NR11, wherein R11 is hydrogen or (C1-C3)alkyl, and wherein said 3- to 8-membered ring is optionally substituted by at least one substituent independently selected from OH, N(ReRf), halo, (C1-C6)alkyl (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, and (C1-C10)alkoxyalkyl; and R10 is hydrogen or (C1-C4)alkyl; wherein, when V is —C(R4R5)— and W is —C(R8R9)— or —N(R10)—, R4 and R8 or R10, together with the atoms to which they are attached, optionally form a saturated or unsaturated 3- to 8-membered ring, wherein said 3- to 8-membered ring is optionally substituted with at least one heteroatom, wherein the at least one heteroatom is independently selected from O, S, N, and NR12, where R12 is hydrogen or (C1-C3)alkyl, and wherein said 3- to 8-membered ring is optionally substituted by at least one substituent independently selected from OH, N(ReRf), halo, (C1-C6)alkyl (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, and (C1-C10)alkoxyalkyl; and R10 is hydrogen or (C1-C4)alkyl; wherein, when V is —N(R6)— and W is —C(R8R9)—, R6 and R8 together with the atoms to which they are attached, optionally form a 3- to 8-membered ring, which is optionally substituted with at least one heteroatom, wherein the at least one heteroatom is independently selected from O, S, N, and NR13, wherein R13 is hydrogen or (C1-C3)alkyl, and wherein said 3- to 8-membered ring is optionally substituted by at least one substituent independently selected from OH, N(ReRf), halo, (C1-C6)alkyl (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, and (C1-C10)alkoxyalkyl; and R10 is hydrogen or (C1-C4)alkyl; X and Y are each independently present or absent, but when present, they are each independently selected from —C(R14R15)—, —N(R16)—, and —C(O)—; wherein R14 and R15 are each independently present or absent, but when present, they are each independently selected from hydrogen, hydroxy, (C1-C10)alkyl, (C1-C5)alkoxy, and ═NH; R16 is hydrogen or (C1-C4)alkyl; or R14 and R15 or R16, together with the atoms to which they are attached, form an cycloalkyl or aryl ring, or a fused aryl or arylalkyl ring structure, optionally substituted with at least one heteroatom, wherein the at least one heteroatom is independently selected from O, S, N, and NR17, where NR17 is hydrogen or (C1-C3)alkyl; and wherein said alkyl or aryl ring, or fused aryl or arylalkyl ring structure is optionally substituted by at least one substituent independently selected from OH, N(ReRf), halo, (C1-C6)alkyl (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, and (C1-C10)alkoxyalkyl; Re and Rf are each independently selected from H and (C1-C4)alkyl; and Z is —(C6-C14)alkyl, —(C6-C14)alkenyl, —(C6-C14)alkynyl, —(C6-C14)alkoxy, —(C6-C20)alkoxyalkyl, —(C3-C12)cycloalkyl, —(C6-C10)aryl, —(C7-C16)alkylaryl, —(C12-C16)alkoxyaryl, —(C6-C20)arylalkyl, —(C4-C1)heterocyclic, —(C4-C10)heteroaryl, or —(C4-C10)heteroaryl(C1-C16)alkyl,wherein the Z groups are optionally substituted with 1, 2, 3, 4, 5, 6, or 7 substituents; wherein the substituents are each independently selected from halo, halo(C1-C7)alkyl, (C1-C7)alkyl, cyano, N(RaRb), (C1-C7)alkoxy, (C1-C7)alkoxyalkyl, (C3-C10)alkoxycycloalkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, (C7-C14)alkylaryl, (C8-C16)acylarylalkyl, (C7-C14)heterocyclic, and (C7-C14)heteroaryl, wherein each substituent may be further optionally substituted and wherein the saturation of each ring substituent may be varied; wherein one or more of the carbon atoms in the Z alkyl groups can be independently replaced with non-peroxide oxygen, sulfur, sulfonyl, or N(Rc); wherein each of Ra, Rb or Rc is independently hydrogen or (C1-C7)alkyl;
with the proviso that the atoms represented by V, W, X, Y, and Z need not be directly connected by a single bond but may be connected via any of the atoms in the ring structures described for V, W, X, and Y; or a pharmaceutically acceptable salt thereof or a prodrug thereof. |
