发明名称 |
COMPOSITIONS AND METHODS FOR INDUCING DIFFERENTIATION OF STEM CELLS |
摘要 |
Compositions and methods for inducing differentiation of stem cells such as cancer stem cells (CSCs), and increasing sensitivity of CSCs to at least one oxidizing agent in a subject include sulindac and/or epimers thereof. These sulindac-based compositions and methods are particularly useful for treating cancers such as glioblastoma (GBM) and for differentiating stem cells in vitro that can be used for cell replacement therapy in a subject in need thereof. |
申请公布号 |
WO2015112311(A1) |
申请公布日期 |
2015.07.30 |
申请号 |
WO2014US72651 |
申请日期 |
2014.12.30 |
申请人 |
BIODEMAK LLC |
发明人 |
LOPEZ-TOLEDANO, MIGUEL;WEISSBACH, HERBERT;KESARAJU, SHAILAJA |
分类号 |
C12N5/079;C12N5/075;C12N5/0797 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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