发明名称 |
HUMAN ANTIBODIES TO PD-L1 |
摘要 |
The present invention provides antibodies that bind to the T-cell co-inhibitor ligand programmed death-ligandl (PD-L1 ) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to PD-L1. In certain embodiments, the present invention provides multi-specific antigen-binding molecules comprising a first binding specificity that binds to PD-L1 and a second binding specificity that binds to a tumor cell antigen, an infected cell-specific antigen, or a T-cell co-inhibitor. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing PD-L1 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection. |
申请公布号 |
CA2937343(A1) |
申请公布日期 |
2015.07.30 |
申请号 |
CA20152937343 |
申请日期 |
2015.01.23 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
PAPADOPOULOS, NICHOLAS J.;MURPHY, ANDREW J.;THURSTON, GAVIN;IOFFE, ELLA;BUROVA, ELENA |
分类号 |
C07K16/28;A61K39/00;A61K39/395;A61P35/00;C07K16/22;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|