MIRNA MODULATORS OF THERMOGENESIS

摘要

Provided are novel methods and compositions for the modulation of thermogenesis. Such methods are particularly advantageous in that they allow for the reduction of body fat in a subject without the subject having to adjust their caloric intake through dieting, modify their physical activity or undergo bariatric surgery. Accordingly, the methods of the invention are particularly useful for treating or preventing obesity. Also provided are methods of screening for novel agents that modulate the activity of thermogenic regulators.

主权项

1. A method of modulating respiratory chain uncoupling in a cell, the method comprising contacting the cell with a miRNA agent that modulates activity of at least one mitochondrial uncoupler.