发明名称 |
GOBLET CELL REPLACEMENT THERAPY |
摘要 |
Described herein is the finding that activators of CXCR3, such as proteins that bind CXCR3 (e.g., IP-9, IP-10 and PF4), enhance the density of goblet cells in the eye. Goblet cells in the conjunctiva are the primary source of tear mucus. Accordingly, the present disclosure describes methods of treating dry eye syndrome by administering an activator of CXCR3. Also described are methods of increasing goblet cells density, such as goblet cell density in the conjunctiva. |
申请公布号 |
CA2935595(A1) |
申请公布日期 |
2015.07.30 |
申请号 |
CA20152935595 |
申请日期 |
2015.01.20 |
申请人 |
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
YATES-BINDER, CECELIA C.;WELLS, ALAN H.;SCHUMAN, JOEL S.;CONNER, IAN P. |
分类号 |
A61K38/19;A61P27/02;A61P27/04;A61P27/06 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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