| 摘要 |
Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided. |
| 主权项 |
1. A recombinant microorganism comprising:
a) at least one EasH activity, or b) at least one EasH and EasD activity, or c) at least one EasH and EasA reductase activity, or d) at least one EasH, EasD and EasA activity, or e) at least one EasH and EasD, EasA reductase and EasG activity, or f) at least one DmaW, EasF, EasE, EasC, EasD, EasH, EasA and EasG activity, or g) at least one EasD, EasA and EasG activity, or h) at least one DmaW, EasF, EasE, EasC, EasD, EasA reductase and EasG activity, or i) at least one DmaW, EasF, EasE, EasC, EasD, EasA isomerase and EasG activity, or j) at least one DmaW, EasF, EasE and EasC activity, or k) a combination of at least two of a) to j).
wherein the recombinant microorganism is not a natural ergot alkaloid producer organism. |
