Antibody specific to staphylococcus aureus, therapeutic method and detection method using same

摘要

We provide new monoclonal antibody inhibitors of coagulases for treatment of S. aureus. The monoclonal antibodies are useful in targeting the SC N-terminus and inhibiting prothrombin activation. The monoclonal antibodies are able to bind to and interfere with, modulate, and/or inhibit the binding interactions between the staphylocoagulase protein and its ligand protein prothrombin in blood and tissues. The antibodies are effective in inhibiting the activation of prothrombin.

主权项

1. An isolated monoclonal antibody which binds an epitope of staphylocoagulase peptide that is within SEQ ID. No: 2 and which comprises the following CDRs:CDRL1:(SEQ ID No: 10)QNVDIYCDRL2:(SEQ ID No.: 11)SASCDRL3:(SEQ ID No: 12)QQYNNYPYTCDRH1:(SEQ ID NO: 13)GFTFSDAWCDRH2:(SEQ ID NO: 14)IRTKANNHATCDRH3:(SEQ ID NO: 15)CTNVYYGNNDVKDY.