| 发明名称 |
IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF |
| 摘要 |
The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2. |
| 申请公布号 |
US2015210754(A1) |
申请公布日期 |
2015.07.30 |
| 申请号 |
US201514678319 |
申请日期 |
2015.04.03 |
| 申请人 |
Omrix Biopharmaceuticals Ltd. |
发明人 |
Mintz Roni;Belyaev Oleg;Nur Israel;Bar Liliana;Meidler Roberto |
| 分类号 |
C07K16/06 |
主分类号 |
C07K16/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for removing a thrombogenic agent from an immunoglobulin containing solution, the method comprising the steps of: providing the immunoglobulin containing solution at a pH in the range of higher than 3.8 to equal to or lower than 5.3; providing a support comprising immobilized negatively charged groups; contacting the solution with the support; and collecting an unbound fraction I. |
| 地址 |
Rehovot IL |
