| 主权项 |
1. A Compound of the formula Iin which
R1 denotes F, Cl, CH3, OCH3, CF3, CHF2 or CH2F, R2 denotes H or unbranched or branched alkyl with 1-6 C-atoms, X denotes C or N, with the proviso that only one X denotes N, Y denotes A, Cyc, [C(R2)2]qOA, [C(R2)2]qN(R2)2, [C(R2)2]pHet1, [C(R2)2]pCOOR2, [C(R2)2]pCON(R2)2 or [C(R2)2]pSO2N(R2)2, Ar denotes phenyl, which is unsubstituted, or mono- or disubstituted by Hal, A, [C(R2)2]pOR, [C(R2)2]pN(R2)2, [C(R2)2]pHet2, NO2, CN, [C(R2)2]pCOOR, [C(R2)2]pN(R2)2, N(R2)2COA, NR2SO2A, [C(R2)2]pSO2N(R2)2, S(O)nA, COHet2, O[C(R2)2]mN(R2)2, O[C(R2)2]pHet2, NHCOOA, NHCON(R2)2 or COA, Het1 denotes pyrrolidinyl, azetidinyl, tetrahydroimidazolyl, tetrahydrofuranyl, oxetanyl, tetrahydropyrazolyl, tetrahydropyranyl, piperidinyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, piperazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl, quinolyl, 1,3-benzodioxolyl, benzothiophenyl, benzofuranyl, imidazopyridyl or furo[3,2-b]pyridyl, each of which is unsubstituted or mono- or disubstituted by Hal, A, [C(R2)2]pOR2, [C(R2)2]pN(R2)2, [C(R2)2]pHet2, [C(R2)2]pOHet2, [C(R2)2]pAr, NO2, CN, [C(R2)2]pCOOR2, [C(R2)2]pCON(R2)2, NR2COA, NR2SO2A, [C(R2)2]pSO2N(R2)2, S(O)nA, COHet2, O[C(R2)2]mN(R2)2, O[C(R2)2]pAr, O[C(R2)2]pHet2, NHCOOA, NHCON(R2)2, CHO, COA, ═S, ═NR and/or ═O, Het2 denotes dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydroimidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, morpholinyl, hexahydro-pyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, tetrahydropyranyl or piperazinyl, each of which is unsubstituted or mono- or disubstituted by Hal, CN, OR2, COOR2, CON(R2)2, S(O)nA, S(O)nAr, COA, A and/or ═O, A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein two adjacent carbon atoms may form a double bond and/or one or two non-adjacent CH— and/or CH2-groups may be replaced by N—, O— and/or S-atoms and wherein 1-7 H-atoms may be replaced by F or Cl, Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by OH, Hal or A, Hal denotes F, Cl, Br or I, n denotes 0, 1 or 2, m denotes 1, 2 or 3, p denotes 0, 1, 2, 3 or 4, q denotes 1, 2, 3 or 4, with the proviso that, if R1 is absent or methyl or methoxy, then Y is not methyl, trifluoromethyl, piperidinomethyl, butyl, 3-methoxy-1-propyl or 4-morpholinyl,
and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
