| 主权项 |
1. A compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein X can be O, S(O)r, NR12, C(O) or CH2; A1 and A2 can each independently be CR2 or N; A3, A4 and A5 can each independently be CR2, C(R2)2, N, or NR19, provided that at least three of A1, A2, A3, A4, A5, and A6 are independently CR2 or C(R2)2; “------” indicates a double or a single bond; R1 can be a C6-20alkyl, a C3-14carbocyclyl, a 3- to 15-membered heterocyclyl, a C6-10aryl, or a five- to 14-membered heteroaryl, wherein the heterocyclyl and the heteroaryl comprising from 1 to 10 heteroatoms independently selected from N, S or O, and wherein R1 may be optionally substituted with from one to six independently selected R6; R2, for each occurrence, can be independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, cyano, carboxy, C1-6alkyl, C1-6haloalkyl, C3-8cycloalkyl, C3-8halocycloalkyl, C1-6alkoxy, C1-6haloalkoxy, C3-8cycloalkoxy, C3-8halocycloalkoxy, C1-6alkanoyl, amino, N—(C1-6alkyl)amino, N,N-di-(C1-6alkyl)amino, C1-6alkoxycarbonyl, C1-6alkanoyloxy, carbamoyl, N—(C1-6alkyl)carbamoyl, N,N-di-(C1-6alkyl)carbamoyl, C1-6alkylamido, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, sulfamoyl, N—(C1-6alkyl)sulfamoyl, N,N-di-(C1-6alkyl)sulfamoyl, and C1-6alkylsulfonamido; R3 can be hydrogen, a halo, C1-6haloalkyl or cyano, provided that when R3 is hydrogen, R1 is a C3-8cycloalkyl which is optionally substituted with from 1 to 6; R4 is a carboxylic acid or a group represented by the following formula:whereinrepresents the point of attachment; provided that when R4 is a carboxylic acid, A1 is N and R1 is a C3-8cycloalkyl which is optionally substituted with from 1 to 6;
R5 can be a C1-6alkylene, C3-8carbocyclyl, a 3- to 8-membered heterocyclyl, C6-10aryl, a 5- to 10-membered heteroaryl, a bridged ring system comprising from 6 to 12 ring members, a spiro ring system comprising from 5-14 ring members, or a bicyclic ring system represented by the following formula: wherein B′ and B″ are independently selected from the group consisting of monocyclic C3-8carbocyclyl, a monocyclic 3- to 8-membered heterocyclyl, phenyl or a 5- to 6-membered heteroaryl; wherein R5 may be optionally substituted with from 1 to 4 independently selected R11; R6, for each occurrence, can be independently selected from the group consisting of halo, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C3-8cycloalkyl, C6-10aryl, C1-6alkoxy-C1-6alkyl, and tri-(C1-6alkyl)silyl; or two R6 that are attached to the same carbon atom may form C3-8spirocycloalkyl or 3- to 8-membered spiroheterocycloalkyl; R7 can be —OH, —C(O)OR15, —C(O)N(R16)2, —C(O)N(R15)—S(O)2R15, —S(O)2OR15, —C(O)NHC(O)R15, —Si(O)OH, —B(OH)2, —N(R15)S(O)2R15, —S(O)2N(R15)2, —O—P(O)(OR15)2, —P(O)(OR15)2, —CN, —S(O)2NHC(O)R15, —C(O)NHS(O)2R15, —C(O)NHOH, —C(O)NHCN, or a heteroaryl or a heterocyclyl selected from the group consisting of formulae (a)-(i′): R8 and R9 can each independently be hydrogen, a carboxy, C1-6alkyl, or a C2-6alkenyl; or R8 and R9 together with the carbon to which they are attached can be —C(═O)—, a C3-8spirocycloalkyl, or a 3- to 8-membered spiroheterocycloalkyl; R10 and R12 can each independently be hydrogen or a C1-6alkyl; R11, for each occurrence, can be independently halo, hydroxyl, nitro, cyano, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, —(CR17R18)p—R7, C1-4haloalkoxy, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C3-8halocycloalkyl, C3-8cycloalkoxy, C3-8halocycloalkoxy, —NRaRb, —C(O)NRaRb, —N(Ra)C(O)Rb, —C(O)Ra, —S(O)rRa, or —N(Ra)S(O)2Rb; R15 for each occurrence can be independently selected from the group consisting of hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C3-8cycloalkenyl, C6-10aryl, a 5 to 14 membered heteroaryl, and a 3 to 15 membered heterocyclyl; wherein the heteroaryl or heterocyclyl comprises from 1 to 10 heteroatoms independently selected from O, N, or S; and wherein R15 may be optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, C1-4alkoxy, C1-4alkyl, cyano, nitro, hydroxyl, amino, N—(C1-4alkyl)amino, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N-di-(C1-4alkyl)carbamoyl, C1-4alkylsulfonamido, sulfamoyl, N—(C1-4alkyl)sulfamoyl, and N,N—(C1-4dialkyl)-sulfamoyl; R16 can be R15; or two R16 together with the nitrogen atom to which they are attached can form a 5 to 14 membered heteroaryl or a 3 to 15 membered heterocyclyl, wherein the heteroaryl or heterocyclyl comprises from 1 to 10 heteroatoms independently selected from O, N, or S; and wherein the heteroaryl or heterocyclyl may be optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, C1-4alkoxy, cyano, nitro, hydroxyl, amino, N—(C1-4alkyl)amino, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N-di-(C1-4alkyl)carbamoyl, C1-4alkylsulfonamido, sulfamoyl, N—C1-4alkylsulfamoyl, and N,N—(C1-4dialkyl)-sulfamoyl; R17 and R18, for each occurrence, can be each independently hydrogen, a halo, or a C1-4haloalkyl; R19 for each occurrence can be independently selected from the group consisting of hydrogen, carboxy, C1-6alkyl, C1-6haloalkyl, C3-8cycloalkyl, C3-8halocycloalkyl, C1-6alkanoyl, C1-6alkoxycarbonyl, carbamoyl, N—(C1-6alkyl)carbamoyl, N,N-di-(C1-6alkyl)carbamoyl, C1-6alkylsulfonyl, sulfamoyl, N—(C1-6alkyl)sulfamoyl, and N,N-di-(C1-6alkyl)sulfamoyl. Ra and Rb, for each occurrence, can be independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C6-10aryl, or C3-8halocycloalkyl; Rc is hydrogen or a C1-4alkyl; m can be 0 or 1, provided that when m is 0, R5 comprises at least one nitrogen; n can be an integer from 1 to 6; p can be 0 or an integer from 1 to 6; r, for each occurrence, can be independently 0, 1, or 2, provided that the compound is not 4,4′-((perfluoronaphthalene-2,7-diyl)bis(methylene))dipyridine, 3-(1,4-dioxaspiro[4.5]decan-8-ylamino)-8-methylisoquinoline-6-carboxylic acid, or (2-methoxy-3-(morpholinomethyl)quinolin-6-yl)(4-methoxycyclohexyl)methanone. |
