| 发明名称 |
Acridone Compounds |
| 摘要 |
(A1) A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia. |
| 申请公布号 |
US2015210645(A1) |
申请公布日期 |
2015.07.30 |
| 申请号 |
US201514623433 |
申请日期 |
2015.02.16 |
| 申请人 |
Oregon Health & Science University ;Government of the United States of America dba The Department of Veterans Affairs |
发明人 |
Riscoe Michael K.;Winter Rolf W.;Kelly Jane X.;Hinrichs David J.;Smilkstein Martin J. |
| 分类号 |
C07D219/14;A61K31/4706;C07D219/06;A61K31/473 |
主分类号 |
C07D219/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound according to the formula or a pharmaceutically acceptable salt thereof; wherein R is H; X is halogen, n is 1-4; Y is —O—, R1 is optionally substituted alkyl; G is —NR10R11; and R10 and R11 independently are H, lower alkyl, aralkyl or together form an aliphatic or aromatic ring optionally including one or more additional heteroatoms. |
| 地址 |
Portland OR US |
